The Hexosamine Biosynthesis Pathway: Regulation and Function
Rutgers, The State University of New Jersey
Abstract
The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N- or O-linked glycosylation, a co- or post-translational modification, respectively, that modulates protein activity and expression. The production of hexosamines can occur via de novo or salvage mechanisms that are catalyzed by metabolic enzymes. Nutrients including glutamine, glucose, acetyl-CoA, and UTP are utilized by the HBP. Together with availability of these nutrients, signaling molecules that respond to environmental signals, such as mTOR, AMPK, and stress-regulated transcription factors, modulate the HBP. This review discusses the regulation of GFAT, the…
Citation impact
- FWCI
- 27.18
- Percentile
- 100%
- References
- 309
Authors
5- APAlysta Paneque
Rutgers, The State University of New Jersey
- HFHarvey Fortus
Rutgers, The State University of New Jersey
- JZJulia Zheng
Rutgers, The State University of New Jersey
- GWGuy Werlen
Rutgers, The State University of New Jersey
- EJEstela JacintoCorresponding
Rutgers, The State University of New Jersey
Topics & keywords
- Glycosylation
- Nucleotide salvage
- Biochemistry
- Nutrient sensing
- Glutamine amidotransferase
- Enzyme
- Biology
- Metabolic pathway