Long COVID: pathophysiological factors and abnormalities of coagulation
Stellenbosch University · University of Manchester · +5 more institutions
Abstract
Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten cases: known as Long COVID. The disease affects ~65 million individuals worldwide. Many pathophysiological processes appear to underlie Long COVID, including viral factors (persistence, reactivation, and bacteriophagic action of SARS CoV-2); host factors (chronic inflammation, metabolic and endocrine dysregulation, immune dysregulation, and autoimmunity); and downstream impacts (tissue damage from the initial infection, tissue hypoxia, host dysbiosis, and autonomic nervous system dysfunction). These mechanisms culminate in the long-term persistence of the disorder characterized by a thrombotic endothelialitis, endothelial…
Citation impact
- FWCI
- 46.74
- Percentile
- 100%
- References
- 244
Authors
6- STSimone Turner
Stellenbosch University
- AKAsad Khan
University of Manchester
- DPDavid Putrino
Icahn School of Medicine at Mount Sinai
- AWAshley Woodcock
Manchester Academic Health Science Centre, University of Manchester
- DBDouglas B. KellCorresponding
University of Liverpool, Stellenbosch University, Novo Nordisk Foundation, Technical University of Denmark
Topics & keywords
- Pathophysiology
- Immunology
- Inflammation
- Medicine
- Immune dysregulation
- Immune system
- Autoimmunity
- Endocrine system
- Good health and well-being