Psychiatric disorders associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database
Zhujiang Hospital · Southern Medical University · +7 more institutions
Abstract
BackgroundWith the increasing use of immune checkpoint inhibitors (ICIs) for tumour immunotherapy, the immune-related adverse events (irAEs) caused by their collateral effect on the immune system pose a key challenge for the clinical application of ICIs. Psychiatric adverse events are a class of adverse events associated with ICIs that are realistically observed in the real world. We aim to provide a comprehensive study and summary of psychiatric adverse events associated with ICIs.MethodsWe obtained ICI adverse reaction reports during January 2012–December 2021 from the FDA Adverse Event Reporting System (FAERS) database. ICI reports underwent screening to minimize the influence of other adverse reactions,…
Citation impact
- FWCI
- 41.01
- Percentile
- 100%
- References
- 64
Authors
10- CZChaozheng Zhou
Zhujiang Hospital, Southern Medical University
- SPShengkun Peng
University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- ALAnqi Lin
Zhujiang Hospital, Southern Medical University
- AJAimin Jiang
Second Military Medical University, Changhai Hospital
- YPYuanxi Peng
Zhujiang Hospital, Southern Medical University
Topics & keywords
- Adverse Event Reporting System
- Medicine
- Adverse effect
- Pharmacovigilance
- Odds ratio
- Database
- Internal medicine
- Psychiatry
- Good health and well-being
Funding
- NNNational Natural Science Foundation of ChinaAwards: 81871859, 82172811, 81802257, 82172750, 81772457
- NSNatural Science Foundation of Guangdong ProvinceAwards: 2021A1515012593, 2018A030313846
- SAScience and Technology Planning Project of Guangdong ProvinceAward: 2019A030317020
- BABasic and Applied Basic Research Foundation of Guangdong Province