Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis

Weeks, Lachelle D.; Niroula, Abhishek; Neuberg, Donna; Wong, Waihay J.; Lindsley, R. Coleman; Luskin, Marlise R.; Berliner, Nancy; Stone, Richard M.; DeAngelo, Daniel J.; Soiffer, Robert J.; Uddin, Md Mesbah; Griffin, Gabriel K.; Vlasschaert, Caitlyn; Gibson, Christopher J.; Jaiswal, Siddhartha; Bick, Alexander G.; Malcovati, Luca; Natarajan, Pradeep; Ebert, Benjamin L.

doi:10.1056/evidoa2200310

articleNEJM EvidenceApr 25, 2023BRONZE OA

Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis

LDLachelle D. Weeks ANAbhishek Niroula DNDonna Neuberg WJWaihay J. Wong RCR. Coleman Lindsley

Dana-Farber Cancer Institute · Harvard University · +10 more institutions

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Abstract

BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS) are defined by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) of 0.02 or greater in the absence and presence of cytopenia, respectively. CHIP/CCUS is highly prevalent in adults, and defining predictors of MN risk would aid clinical management and research.

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291

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Topics & keywords

Topics

Keywords

Cytopenia
Oncology
Internal medicine
Medicine
Proportional hazards model
Confounding
Bone marrow

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