Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine
University of North Carolina at Chapel Hill · University Health Network · +3 more institutions
Abstract
Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT and PTT at the cellular, vascular and tumor microenvironmental levels, as well as translating both modalities in the clinic. Emerging evidence suggests that PDT and PTT may synergize due to their different mechanisms of action, and their nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations have gained momentum in recent years due to the development of multimodal nanoplatforms that…
Citation impact
- FWCI
- 121.36
- Percentile
- 100%
- References
- 246
Authors
4- MOMarta Overchuk
University of North Carolina at Chapel Hill, University Health Network, North Carolina State University, Princess Margaret Cancer Centre
- RWRobert Weersink
University Health Network, University of Toronto, Princess Margaret Cancer Centre
- BCBrian C. Wilson
University Health Network, University of Toronto, Princess Margaret Cancer Centre
- GZGang ZhengCorresponding
University Health Network, University of Toronto, Princess Margaret Cancer Centre
Topics & keywords
- Photodynamic therapy
- Photothermal therapy
- Nanomedicine
- Modalities
- Rational design
- Nanotechnology
- Drug delivery
- Medicine
- Good health and well-being