reviewThe Lancet MicrobeApr 27, 2023GOLD OA

Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap

FDFarnaz DaneshniaJNJoão Nóbrega de AlmeidaMİMacit İlkitLLLisa LombardiAMAustin M. Perry

Massachusetts General Hospital · Institute for Biodiversity · +24 more institutions

PubMed
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Abstract

Candida parapsilosis is one of the most commen causes of life-threatening candidaemia, particularly in premature neonates, individuals with cancer of the haematopoietic system, and recipients of organ transplants. Historically, drug-susceptible strains have been linked to clonal outbreaks. However, worldwide studies started since 2018 have reported severe outbreaks among adults caused by fluconazole-resistant strains. Outbreaks caused by fluconazole-resistant strains are associated with high mortality rates and can persist despite strict infection control strategies. The emergence of resistance threatens the efficacy of azoles, which is the most widely used class of antifungals and the only available oral…

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226
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41.83
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100%
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15

Topics & keywords

Topics
Keywords
  • Fluconazole
  • Candida parapsilosis
  • Outbreak
  • Echinocandin
  • Azole
  • Biology
  • Drug resistance
  • Intensive care medicine
UN Sustainable Development Goals
  • Good health and well-being
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