Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs
Indo Soviet Friendship College of Pharmacy · Åbo Akademi University
Abstract
A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70-90% of drug candidates in the development stage are poorly soluble, which results in low bioavailability, diminished therapeutic effects, and dosage escalation. Because of this, solubility must be taken into consideration when developing and fabricating pharmaceutical products. To date, a number of approaches have been investigated to address the problem of poor solubility. This review article attempts to summarize several conventional methods utilized to increase the…
Citation impact
- FWCI
- 21.27
- Percentile
- 100%
- References
- 190
Authors
8Topics & keywords
- Bioavailability
- Solubilization
- Chemistry
- Pharmacology
- Medicine
- Biochemistry