Gelatin Methacryloyl Hydrogel, from Standardization, Performance, to Biomedical Application

Gelatin methacryloyl (GelMA), a photocurable hydrogel, is widely used in 3D culture, particularly in 3D bioprinting, due to its high biocompatibility, tunable physicochemical properties, and excellent formability. However, as the properties and performances of GelMA vary under different synthetic conditions, there is a lack of standardization, leading to conflicting results. In this study, a uniform standard is established to understand and enhance GelMA applications. First, the basic concept of GelMA and the density of the molecular network (DMN) are defined. Second, two properties, degrees of substitution and ratio of solid content, as the main measurable parameters determining the DMN are used. Third, the…

• NN
  National Natural Science Foundation of China

  Awards: U1909218, 52235007
• NK
  National Key Research and Development Program of China

  Award: 2018YFA0703000