Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes

Legacy per- and polyfluoroalkyl substances (PFASs) have elicited much concern because of their ubiquitous distribution in the environment and the potential hazards they pose to wildlife and human health. Although an increasing number of effective PFAS alternatives are available in the market, these alternatives bring new challenges. This paper comprehensively reviews how PFASs bind to transport proteins (e.g., serum albumin, liver fatty acid transport proteins and organic acid transporters), nuclear receptors (e.g., peroxisome proliferator activated receptors, thyroid hormone receptors and reproductive hormone receptors) and membranes (e.g., cell membrane and mitochondrial membrane). Briefly, the hydrophobic…

• CA
  China Association for Science and Technology

  Award: 2022QNRC001
• SK
  State Key Laboratory in Marine Pollution
• NN
  National Natural Science Foundation of China

  Award: 42207335
• MO
  Ministry of Science and Technology of the People's Republic of China
• IA
  Innovation and Technology Commission

  Award: PJ9448002
• CA
  China Academy of Space Technology
• NK
  National Key Research and Development Program of China

  Award: 2021YFC3201000