Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on the backbones or amino acid side chains of proteins and expand the diversity of proteins, which provides the basis for the emergence of organismal complexity. To date, more than 650 types of protein modifications, such as the most well-known phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, short-chain and long-chain acylation modifications, redox modifications, and irreversible modifications, have been described, and the inventory is still increasing. By changing the protein conformation, localization, activity, stability, charges, and interactions with other biomolecules, PTMs…

• NN
  National Natural Science Foundation of China

  Awards: 31870826, 82073221, 82073246
• SP
  Sichuan Province Science and Technology Support Program

  Award: 2023YFS0247
• WC
  West China Hospital, Sichuan University

  Awards: Z2021JC005, ZYYC20007