Glioblastoma remodelling of human neural circuits decreases survival
University of California, San Francisco · Neurological Surgery · +3 more institutions
Abstract
. Here we sought to determine how glioma-induced neuronal changes influence neural circuits underlying cognition and whether these interactions influence patient survival. Using intracranial brain recordings during lexical retrieval language tasks in awake humans together with site-specific tumour tissue biopsies and cell biology experiments, we find that gliomas remodel functional neural circuitry such that task-relevant neural responses activate tumour-infiltrated cortex well beyond the cortical regions that are normally recruited in the healthy brain. Site-directed biopsies from regions within the tumour that exhibit high functional connectivity between the tumour and the rest of the brain are enriched for…
Citation impact
- FWCI
- 50.88
- Percentile
- 100%
- References
- 94
Authors
29- SKSaritha KrishnaCorresponding
University of California, San Francisco, Neurological Surgery
- ACAbrar Choudhury
University of California, San Francisco, Neurological Surgery
- MBMichael B. Keough
Stanford University
- KSKyounghee Seo
University of California, San Francisco, Neurological Surgery
- LNLijun Ni
Stanford University
Topics & keywords
- Glioma
- Neuroscience
- Biological neural network
- Biology
- Human brain
- Cancer research