articleNucleic Acids ResearchMay 4, 2023GOLD OA

antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation

Novo Nordisk Foundation · Technical University of Denmark · +6 more institutions

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Abstract

Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds. Since 2011, the 'antibiotics and secondary metabolite analysis shell-antiSMASH' (https://antismash.secondarymetabolites.org/) has supported researchers in their microbial genome mining tasks, both as a free to use web server and as a standalone tool under an OSI-approved open source…

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