Viral persistence, reactivation, and mechanisms of long COVID
Icahn School of Medicine at Mount Sinai · Ragon Institute of MGH, MIT and Harvard · +5 more institutions
Abstract
The COVID-19 global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has infected hundreds of millions of individuals. Following COVID-19 infection, a subset can develop a wide range of chronic symptoms affecting diverse organ systems referred to as post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. A National Institutes of Health-sponsored initiative, RECOVER: Researching COVID to Enhance Recovery, has sought to understand the basis of long COVID in a large cohort. Given the range of symptoms that occur in long COVID, the mechanisms that may underlie these diverse symptoms may also be diverse. In this review, we focus on the emerging…
Citation impact
- FWCI
- 36.55
- Percentile
- 100%
- References
- 101
Authors
5- BKBenjamin K. ChenCorresponding
Icahn School of Medicine at Mount Sinai
- BJBoris Jülg
Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital
- SMSindhu Mohandas
University of Southern California, Children's Hospital of Los Angeles
- SBSteven B. Bradfute
University of New Mexico, Center for Global Health
- RMRECOVER Mechanistic Pathways Task Force
Topics & keywords
- Persistence (discontinuity)
- Coronavirus disease 2019 (COVID-19)
- Immune system
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Coronavirus
- Biology
- Pandemic
- Immunology
- Good health and well-being