articleNew England Journal of MedicineMay 5, 2023Closed access

Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy

Australian National University · Camden and Campbelltown Hospitals · +14 more institutions

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Abstract

Background

Whether treatment of gestational diabetes before 20 weeks' gestation improves maternal and infant health is unclear.

Methods

We randomly assigned, in a 1:1 ratio, women between 4 weeks' and 19 weeks 6 days' gestation who had a risk factor for hyperglycemia and a diagnosis of gestational diabetes (World Health Organization 2013 criteria) to receive immediate treatment for gestational diabetes or deferred or no treatment, depending on the results of a repeat oral glucose-tolerance test [OGTT] at 24 to 28 weeks' gestation (control). The trial included three primary outcomes: a composite of adverse neonatal outcomes (birth at

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Funding