Efficient NIR-II Type-I AIE Photosensitizer for Mitochondria-Targeted Photodynamic Therapy through Synergistic Apoptosis–Ferroptosis
Shaanxi Normal University · Chinese University of Hong Kong, Shenzhen
Abstract
Hypoxia, the hallmark of malignant tumors, has been recognized as a major obstacle for photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological scenarios by a hypoxia-resistant photosensitizer (PS) is the cornerstone to conquer the inevitable tumor recurrence and metastasis. Herein, we describe an organic NIR-II PS (TPEQM-DMA) possessing potent type-I phototherapeutic efficacy to overcome the intrinsic pitfalls of PDT in combating hypoxic tumors. TPEQM-DMA exhibited prominent NIR-II emission (>1000 nm) with an aggregation-induced emission feature and efficiently produced superoxide anion and hydroxyl radical in the aggregate state under white light irradiation exclusively through a…
Citation impact
- FWCI
- 20.43
- Percentile
- 100%
- References
- 71
Authors
7Topics & keywords
- Photosensitizer
- Photodynamic therapy
- Reactive oxygen species
- Chemistry
- Biophysics
- Apoptosis
- Cancer cell
- Mitochondrion
- Good health and well-being