Denoising diffusion probabilistic models for 3D medical image generation
Universitätsklinikum Aachen · RWTH Aachen University · +7 more institutions
Abstract
Recent advances in computer vision have shown promising results in image generation. Diffusion probabilistic models have generated realistic images from textual input, as demonstrated by DALL-E 2, Imagen, and Stable Diffusion. However, their use in medicine, where imaging data typically comprises three-dimensional volumes, has not been systematically evaluated. Synthetic images may play a crucial role in privacy-preserving artificial intelligence and can also be used to augment small datasets. We show that diffusion probabilistic models can synthesize high-quality medical data for magnetic resonance imaging (MRI) and computed tomography (CT). For quantitative evaluation, two radiologists rated the quality of…
Citation impact
- FWCI
- 48.38
- Percentile
- 100%
- References
- 32
Authors
15Topics & keywords
- Computer science
- Probabilistic logic
- Artificial intelligence
- Correctness
- Synthetic data
- Medical imaging
- Segmentation
- Image quality
Funding
- UDU.S. Department of DefenseAwards: U01 AG024904, W81XWH, W81XWH-12-2-, W81XWH-12-2-0012, AG024904
- FFFoundation for the National Institutes of HealthAwards: W81XWH-12-2-0012, Grant U01 AG024904, AG024904, U01 AG024904
- AAAlzheimer's AssociationAwards: U01 AG024904, W81XWH-12-2-0012
- BSBristol-Myers SquibbAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- ELEli Lilly and CompanyAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- PPfizerAwards: AG024904, W81XWH-12-2-0012, U01 AG024904
- BBiogenAwards: W81XWH-12-2-0012, U01 AG024904, AG024904
- UOUniversity of Southern CaliforniaAwards: W81XWH-12-2-0012, U01 AG024904
- FHF. Hoffmann-La RocheAwards: W81XWH-12-2-0012, AG024904, U01 AG024904
- MSMeso Scale DiagnosticsAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- ADAlzheimer's Disease Neuroimaging InitiativeAwards: AG024904, W81XWH-12-2-, W81XWH-12-2-0012, Department of Defense award number W81XWH-12-2-0012, U01 AG024904
- BBioClinicaAwards: U01 AG024904, W81XWH-12-2-0012, AG024904
- NPNovartis Pharmaceuticals CorporationAwards: W81XWH-12-2-0012, U01 AG024904, AG024904
- NCNorthern California Institute for Research and EducationAwards: U01 AG024904, W81XWH-12-2-0012
- EEisaiAwards: W81XWH-12-2-0012, U01 AG024904, AG024904
- RARWTH Aachen University
- SServierAwards: AG024904, W81XWH-12-2-0012, U01 AG024904
- HLH. Lundbeck A/SAwards: U01 AG024904, AG024904, W81XWH-12-2-0012
- IIXICOAwards: AG024904, W81XWH-12-2-0012, U01 AG024904
- NINational Institutes of HealthAwards: AG024904, U01 AG024904, W81XWH, Grant U01 AG024904, W81XWH-12-2-0012
- GGenentechAwards: W81XWH-12-2-0012, AG024904, U01 AG024904
- CICanadian Institutes of Health ResearchAwards: U01 AG024904, W81XWH-12-2-0012
- NINational Institute on AgingAwards: U01 AG024904, W81XWH-12-2-0012, AG024904
- NINational Institute of Biomedical Imaging and BioengineeringAwards: W81XWH-12-2-0012, U01 AG024904, AG024904