articleNucleic Acids ResearchMay 11, 2023GOLD OA

Enrichr-KG: bridging enrichment analysis across multiple libraries

JEJohn Erol EvangelistaZXZhuorui XieGBGiacomo B. MarinoNNNhi NguyenDCDaniel Clarke

Icahn School of Medicine at Mount Sinai

PubMed
Indexed incrossrefdoajpubmed

Abstract

Gene and protein set enrichment analysis is a critical step in the analysis of data collected from omics experiments. Enrichr is a popular gene set enrichment analysis web-server search engine that contains hundreds of thousands of annotated gene sets. While Enrichr has been useful in providing enrichment analysis with many gene set libraries from different categories, integrating enrichment results across libraries and domains of knowledge can further hypothesis generation. To this end, Enrichr-KG is a knowledge graph database and a web-server application that combines selected gene set libraries from Enrichr for integrative enrichment analysis and visualization. The enrichment results are presented as…

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Topics
Keywords
  • Biology
  • Bridging (networking)
  • Computational biology
  • Genetics
  • Computer science
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