Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
Sichuan University · State Key Laboratory of Biotherapy · +4 more institutions
Abstract
In the past period, due to the rapid development of next-generation sequencing technology, accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic response. More importantly, available evidence seems to indicate that modulating the composition of the gut microbiota to improve the efficacy of anti-cancer drugs may be feasible. However, intricate complexities exist, and a deep and comprehensive understanding of how the human microbiota interacts with cancer is critical to realize its full potential in cancer treatment. The purpose of this review is to summarize the initial clues on molecular mechanisms regarding the mutual effects between the…
Citation impact
- FWCI
- 45.06
- Percentile
- 100%
- References
- 436
Authors
10- LZLin-Yong ZhaoCorresponding
Sichuan University, State Key Laboratory of Biotherapy
- JMJia-Xin Mei
Sichuan University, State Key Laboratory of Biotherapy
- GYGang Yu
Sichuan University, State Key Laboratory of Biotherapy
- LLLei Lei
Sichuan University, West China Hospital of Sichuan University, State Key Laboratory of Oral Diseases
- WZWeihan Zhang
Sichuan University, State Key Laboratory of Biotherapy
Topics & keywords
- Gut flora
- Cancer
- Cancer therapy
- Cancer treatment
- Radiation therapy
- Cancer immunotherapy
- Immunotherapy
- Bioinformatics
- Good health and well-being