Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

Tamura, Tomokazu; Ito, Jumpei; Uriu, Keiya; Zahradník, Jiří; Kida, Izumi; Anraku, Yuki; Nasser, Hesham; Shofa, Maya; Oda, Yoshitaka; Lytras, Spyros; Nao, Naganori; Itakura, Yukari; Deguchi, Sayaka; Suzuki, Rigel; Wang, Lei; Begum, MST Monira; Kita, Shunsuke; Yajima, Hisano; Sasaki, Jiei; Sasaki‐Tabata, Kaori; Shimizu, Ryo; Tsuda, Masumi; Kosugi, Yusuke; Fujita, Shigeru; Pan, Lin; Sauter, Daniel; Yoshimatsu, Kumiko; Suzuki, Saori; Asakura, Hiroyuki; Nagashima, Mami; Sadamasu, Kenji; Yoshimura, Kazuhisa; Yamamoto, Yuki; Nagamoto, Tetsuharu; Schreiber, Gideon; Maenaka, Katsumi; Ito, Hayato; Misawa, Naoko; Kimura, Izumi; Suganami, Mai; Chiba, Mika; Yoshimura, Ryo; Yasuda, Kyoko; Iida, Keiko; Ohsumi, Naomi; Strange, Adam; Takahashi, Otowa; Ichihara, Kimiko; Shibatani, Yuki; Nishiuchi, Tomoko; Kato, Marie; Ferdous, Zannatul; Mouri, Hiromi; Shishido, Kenji; Sawa, Hirofumi; Hashimoto, Rina; Watanabe, Yukio; Sakamoto, Ayaka; Yasuhara, Naoko; Suzuki, Tateki; Kimura, Kanako; Nakajima, Yukari; Nakagawa, So; Wu, Jiaqi; Shirakawa, Kotaro; Takaori‐Kondo, Akifumi; Nagata, Kayoko; Kazuma, Yasuhiro; Nomura, Ryosuke; Horisawa, Yoshihito; Tashiro, Yusuke; Kawai, Yugo; Irie, Takashi; Kawabata, Ryoko; Motozono, Chihiro; Toyoda, Mako; Ueno, Takamasa; Hashiguchi, Takao; Ikeda, Terumasa; Fukuhara, Takasuke; Saito, Akatsuki; Tanaka, Shinya; Matsuno, Keita; Takayama, Kazuo; Sato, Kei

doi:10.1038/s41467-023-38435-3

articleNature CommunicationsMay 16, 2023GOLD OA

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

TTTomokazu Tamura JIJumpei Ito KUKeiya Uriu JZJiří Zahradník IKIzumi Kida

Hokkaido University · The University of Tokyo · +22 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the…

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Topics & keywords

Topics

Keywords

Recombination
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Coronavirus disease 2019 (COVID-19)
2019-20 coronavirus outbreak
Virology
Sars virus
Biology
Betacoronavirus

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