reviewNatureMay 17, 2023HYBRID OA

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

EPErola Pairo‐CastineiraKRKonrad RawlikADAndrew D. BretherickTQTing QiYWYang Wu

Roslin Institute · Western General Hospital · +423 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group 3 . Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a…

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Topics & keywords

Topics
Keywords
  • Coronavirus disease 2019 (COVID-19)
  • Genome-wide association study
  • 2019-20 coronavirus outbreak
  • Homogeneous
  • Phenotype
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Genetic variants
  • Meta-analysis
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