Drug-induced oxidative stress in cancer treatments: Angel or devil?

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the most significant biological events in cancer progression. Cancer cells generally represent a higher oxidant level, which suggests a dual therapeutic strategy by regulating redox status (i.e., pro-oxidant therapy and/or antioxidant therapy). Indeed, pro-oxidant therapy exhibits a great anti-cancer capability, attributing to a higher oxidant accumulation within cancer cells, whereas antioxidant therapy to restore redox homeostasis has been claimed to fail in several clinical practices. Targeting the redox vulnerability of cancer cells by pro-oxidants capable of generating excessive reactive oxygen species (ROS) has…

• NN
  National Natural Science Foundation of China

  Award: 81821002
• DO
  Department of Education, Heilongjiang Province

  Award: SJGY20200447
• DO
  Department of Science and Technology of Sichuan Province
• WJ
  Wu Jieping Medical Foundation

  Awards: 320.6750.18492, 320.6750
• NS
  Natural Science Foundation of Ningbo

  Award: 2022J236
• SP
  Sichuan Province Science and Technology Support Program

  Award: 2021YFG0137
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2019B030302012