Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the clearance of pathogens. However, pyroptosis is a double-edged sword. Numerous studies have revealed the relationship between abnormal GSDMD activation and various inflammatory diseases, including sepsis, coronavirus disease 2019 (COVID-19), neurodegenerative diseases, nonalcoholic steatohepatitis (NASH), inflammatory bowel disease (IBD), and malignant tumors. GSDMD, a key pyroptosis-executing protein, is linked to inflammatory signal transduction, activation of…

• NN
  National Natural Science Foundation of China

  Award: 82204220
• NS
  Natural Science Foundation of Sichuan Province

  Award: 2023NSFSC1689
• SP
  Special Project for Research and Development in Key areas of Guangdong Province