Organoids: The current status and biomedical applications
Sichuan University · West China Hospital of Sichuan University · +3 more institutions
Abstract
Abstract Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are derived from cells with stem potential and can self‐organize and differentiate into 3D cell masses, recapitulating the morphology and functions of their in vivo counterparts. Organoid culture is an emerging 3D culture technology, and organoids derived from various organs and tissues, such as the brain, lung, heart, liver, and kidney, have been generated. Compared with traditional bidimensional culture, organoid culture systems have the unique advantage of conserving parental gene expression and mutation characteristics, as well as long‐term maintenance of the function and biological characteristics of the parental…
Citation impact
- FWCI
- 24.75
- Percentile
- 100%
- References
- 350
Authors
10- SYSiqi Yang
Sichuan University, West China Hospital of Sichuan University, Zero to Three
- HHHai‐Jie Hu
Sichuan University, West China Hospital of Sichuan University, Zero to Three
- HKHeng‐Chung Kung
Johns Hopkins University
- RZRui-Qi Zou
Sichuan University, West China Hospital of Sichuan University
- YDYu-Shi Dai
Sichuan University, West China Hospital of Sichuan University
Topics & keywords
- Organoid
- Current (fluid)
- Computational biology
- Biology
- Medicine
- Data science
- Computer science
- Neuroscience
Funding
- NNNational Natural Science Foundation of ChinaAward: 82203782
- CPChina Postdoctoral Science FoundationAward: 2021M692277
- SUSichuan UniversityAwards: ZYJC21046, 2021HXFH001, 2021HXBH127, 2021CDZG-23
- NSNatural Science Foundation of Sichuan ProvinceAward: 2022NSFSC0806
- WCWest China Hospital, Sichuan UniversityAwards: ZYJC21046, 2021HXFH001, 2021HXBH127