Radiation-induced tumor immune microenvironments and potential targets for combination therapy

As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. During RT, alterations in signaling pathways result in changes in the local immune microenvironment. However, some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under…

• NN
  National Natural Science Foundation of China

  Awards: 81930079, 82173089, 82073142, 82273275, 82073332, U22A2031, 82073151
• CS
  Chinese Society of Clinical Oncology

  Awards: Y-2020Sciclone/ms-0099, Y-2019Sciclone-019
• DO
  Department of Health of Zhejiang Province

  Awards: 2021RC063, 2021KY697
• NK
  National Key Research and Development Program of China

  Award: 2022YFA1105200
• MS
  Medical Science and Technology Project of Zhejiang Province

  Awards: 2021RC063, 2021KY697
• NS
  Natural Science Foundation of Zhejiang Province

  Awards: LGF22H060010, LR19H160001, LY21H100004, LY19H160050
• SA
  Science and Technology Program of Zhejiang Province