MS-Based Proteomics of Body Fluids: The End of the Beginning
Max Planck Institute of Biochemistry · University of Copenhagen · +1 more institution
Abstract
Accurate biomarkers are a crucial and necessary precondition for precision medicine, yet existing ones are often unspecific and new ones have been very slow to enter the clinic. Mass spectrometry (MS)-based proteomics excels by its untargeted nature, specificity of identification, and quantification, making it an ideal technology for biomarker discovery and routine measurement. It has unique attributes compared to affinity binder technologies, such as OLINK Proximity Extension Assay and SOMAscan. In in a previous review in 2017, we described technological and conceptual limitations that had held back success. We proposed a 'rectangular strategy' to better separate true biomarkers by minimizing cohort-specific…
Citation impact
- FWCI
- 28.77
- Percentile
- 100%
- References
- 141
Authors
3Topics & keywords
- Proteomics
- Computational biology
- Chemistry
- Biology
- Biochemistry
Funding
- IMInternational Max Planck Research School for Environmental, Cellular and Molecular Microbiology
- DFDeutsche ForschungsgemeinschaftAward: 412136960
- BFBundesministerium für Bildung und Forschung
- MMax-Planck-Gesellschaft
- NNNovo Nordisk
- NNNovo Nordisk Fonden
- BFBundesministerium für Bildung, Wissenschaft, Forschung und Technologie
- IMInternational Max Planck Research School for Advanced Methods in Process and Systems Engineering