Intricacies of TGF-β signaling in Treg and Th17 cell biology

Helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens. Dysregulation of Th cell function often leads to maladies, including autoimmunity, inflammatory disease, cancer, and infection. Regulatory T (Treg) and Th17 cells are critical Th cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. It is therefore critical to understand how Treg and Th17 cells are regulated in health and disease. Cytokines are instrumental in directing Treg and Th17 cell function. The evolutionarily conserved TGF-β (transforming growth factor-β) cytokine superfamily is of particular…

• NM
  National Multiple Sclerosis Society

  Award: RG-1802-30483
• MS
  Multiple Sclerosis Society
• NI
  National Institutes of Health

  Award: AI123193
• NI
  National Institute on Aging

  Award: R56 AG071256
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: R01 AI123193, R01 AI160774