reviewSignal Transduction and Targeted TherapyMay 22, 2023GOLD OA

Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

JYJing YangJXJin XuWWWei WangBZBo ZhangXYXianjun Yu

Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification, and noncoding RNAs modulate many biological processes that are crucial to the development of cancers. Dysregulation of the epigenome drives aberrant transcriptional programs. A growing body of evidence suggests that the mechanisms of epigenetic modification are dysregulated in human cancers and might be excellent targets for tumor treatment. Epigenetics has also been shown to influence tumor immunogenicity and immune cells involved in antitumor responses. Thus, the development and application of epigenetic therapy and cancer immunotherapy…

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336
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100%
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Authors

6

Topics & keywords

Topics
Keywords
  • Epigenetics
  • Epigenome
  • Tumor microenvironment
  • Epigenetic therapy
  • Biology
  • DNA methylation
  • Chromatin
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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