Molecular mechanisms of ischemia and glutamate excitotoxicity

Neves, Diogo; Salazar, Ivan L.; Almeida, Ramiro D.; Silva, Raquel M.

doi:10.1016/j.lfs.2023.121814

reviewLife SciencesMay 25, 2023HYBRID OA

Molecular mechanisms of ischemia and glutamate excitotoxicity

DNDiogo Neves ILIvan L. Salazar RDRamiro D. Almeida RMRaquel M. Silva

University of Aveiro · University of Coimbra · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs). Excitotoxicity is common to several chronic disorders of the Central Nervous System (CNS) and is considered the primary mechanism of neuronal loss of function and cell death in acute CNS diseases (e.g. ischemic stroke). Multiple mechanisms and pathways lead to excitotoxic cell damage including pro-death signaling cascade events downstream of glutamate receptors, calcium (Ca2+) overload, oxidative stress, mitochondrial impairment,…

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189

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FWCI: 21.90
Percentile: 100%
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Topics & keywords

Topics

Keywords

Excitotoxicity
Glutamate receptor
Neuroscience
NMDA receptor
Neuroprotection
Biology
Receptor
Cell biology

UN Sustainable Development Goals

Good health and well-being

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