articleNatureMay 24, 2023HYBRID OA

Tumour extracellular vesicles and particles induce liver metabolic dysfunction

GWGang WangJLJianlong LiLBLinda BojmarHCHaiyan ChenZLZhong Li

Cornell University · Children's Cancer and Blood Foundation · +17 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Cancer alters the function of multiple organs beyond those targeted by metastasis1,2. Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of systemically affected livers in mouse models and in patients with extrahepatic metastasis. We identified tumour-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumour EVP secretion via depletion of Rab27a. All EVP subpopulations, exosomes and principally exomeres, could dysregulate hepatic function. The fatty acid cargo of tumour EVPs—particularly palmitic acid—induced secretion of tumour necrosis factor (TNF) by Kupffer cells, generating…

Citation impact

255
total citations
FWCI
38.81
Percentile
100%
References
51
Citations per year

Authors

43

Topics & keywords

Topics
Keywords
  • Cancer research
  • Biology
  • Steatohepatitis
  • Fatty liver
  • Metastasis
  • Cancer
  • Internal medicine
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding