Flow-induced reprogramming of endothelial cells in atherosclerosis
Georgia Institute of Technology · Emory University · +1 more institution
Abstract
Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral artery disease continue to be leading causes of death worldwide despite the success of treatments with cholesterol-lowering drugs and drug-eluting stents, raising the need to identify additional therapeutic targets. Interestingly, atherosclerosis preferentially develops in curved and branching arterial regions, where endothelial cells are exposed to disturbed blood flow with characteristic low-magnitude oscillatory shear stress. By contrast, straight arterial regions exposed to stable flow, which is associated with high-magnitude, unidirectional shear stress, are relatively well protected from the disease through…
Citation impact
- FWCI
- 34.33
- Percentile
- 100%
- References
- 290
Authors
5- IAIan A. TamargoCorresponding
Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering
- KIKyung In Baek
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- YKYerin Kim
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- CPChristian Park
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- HJHanjoong Jo
Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering
Topics & keywords
- Medicine
- Endothelial dysfunction
- Endothelial stem cell
- Endothelium
- Reprogramming
- Inflammation
- Cell biology
- Vasculogenesis
- Good health and well-being