Understanding and targeting resistance mechanisms in cancer

Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can arise from genetic, epigenetic, and microenvironmental factors. Various mechanisms have been discovered and extensively studied, including drug inactivation, reduced intracellular drug accumulation by reduced uptake or increased efflux, drug target alteration, activation of compensatory pathways for cell survival, regulation of DNA repair and cell death, tumor plasticity, and the regulation from tumor microenvironments (TMEs). To overcome cancer resistance, a…

• NN
  National Natural Science Foundation of China

  Awards: 2018YFA0902801, 32270815
• SY
  Sun Yat-sen University

  Award: ZSQYBRJH0001
• NK
  National Key Research and Development Program of China

  Award: 2018YFA0902801
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2021A1515010117, 2018YFA0902801