Immune-related adverse events of immune checkpoint inhibitors: a review
University of Electronic Science and Technology of China · Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Abstract
Since the first Immune Checkpoint Inhibitor was developed, tumor immunotherapy has entered a new era, and the response rate and survival rate of many cancers have also been improved. Despite the success of immune checkpoint inhibitors, resistance limits the number of patients who can achieve a lasting response, and immune-related adverse events complicate treatment. The mechanism of immune-related adverse events (irAEs) is unclear. We summarize and discuss the mechanisms of action of immune checkpoint inhibitors, the different types of immune-related adverse events and their possible mechanisms, and describe possible strategies and targets for prevention and therapeutic interventions to mitigate them.
Citation impact
- FWCI
- 79.23
- Percentile
- 100%
- References
- 160
Authors
8- QYQinan Yin
University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- LWLiuyun Wu
University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- LHLizhu Han
University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- XZXingyue Zheng
University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- RTRongsheng Tong
University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Topics & keywords
- Immune system
- Adverse effect
- Immunotherapy
- Immune checkpoint
- Medicine
- Immunology
- Internal medicine
- Good health and well-being