Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review
University of Lisbon · Institute for Biotechnology and Bioengineering · +3 more institutions
Abstract
Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability.…
Citation impact
- FWCI
- 43.70
- Percentile
- 100%
- References
- 170
Authors
6- CVCláudia Viegas
University of Lisbon, Institute for Biotechnology and Bioengineering, University of Algarve
- ABAna B. Patrício
University of Lisbon, Institute for Biotechnology and Bioengineering
- JPJoão Prata
University of Lisbon, Institute for Biotechnology and Bioengineering
- ANAkhtar Nadhman
CECOS University
- PKPavan Kumar Chintamaneni
GITAM University
Topics & keywords
- Solid lipid nanoparticle
- Nanocarriers
- Drug carrier
- Drug delivery
- Nanoparticle
- Bioavailability
- Chemistry
- Nanotechnology
- Good health and well-being
Funding
- IFInstitute for Bioengineering and BiosciencesAwards: LA/P/0140/2020, UIDB/04565/2020, UIDP/04565/2020
- CDCentro de Ciências do MarAwards: UIDB/04326/2020, LA/P/0101/2020, UIDP/04326/2020
- FPFundação para a Ciência e a TecnologiaAwards: UIDB/04565/2020, LA/P/0101/2020, Bioeconomy-i4HB, UIDP/04565/2020, 2020.08839.BD, UIDB/04326/2020, UIDP/04326/2020, projects UIDB/04326/2020, LA/P/0140/2020