Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
University of Science and Technology of China · Sun Yat-sen University · +5 more institutions
Abstract
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is metabolic diseases, which affect people of all ages and usually manifest their pathobiology through life-threatening cardiovascular complications. A comprehensive understanding of the pathobiology of metabolic diseases will generate novel targets for improved therapies across the common metabolic spectrum. Protein posttranslational modification (PTM) is an important term that refers to biochemical modification of specific amino acid residues in target proteins, which immensely increases the functional diversity of the proteome. The range of PTMs includes…
Citation impact
- FWCI
- 33.14
- Percentile
- 100%
- References
- 597
Authors
7- XWXiumei WuCorresponding
University of Science and Technology of China, Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University
- MXMengyun Xu
University of Science and Technology of China
- MGMengya Geng
University of Science and Technology of China
- SCShuo Chen
University of Science and Technology of China
- PJPeter J. Little
The University of Queensland, University of the Sunshine Coast, Sunshine Coast University Hospital
Topics & keywords
- Computational biology
- Medicine
- Bioinformatics
- Biology
- Good health and well-being
Funding
- NNNational Natural Science Foundation of ChinaAwards: 81530025, 2017BT01S131, 82070464, 2021YFC2500500, 81941022
- CAChinese Academy of Sciences
- UOUniversity of Science and Technology of ChinaAward: CXGG02
- GPGuangdong Provincial Pearl River Talents ProgramAward: 2017BT01S131
- NSNatural Science Foundation of Anhui ProvinceAwards: No. 2208085J08, 2208085J08