Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

Abnormal α-synuclein aggregation is a key pathological feature of a group of neurodegenerative diseases known as synucleinopathies, which include Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy (MSA). The pathogenic β-sheet seed conformation of α-synuclein is found in various tissues, suggesting potential as a biomarker, but few studies have been able to reliably detect these seeds in serum samples. In this study, we developed a modified assay system, called immunoprecipitation-based real-time quaking-induced conversion (IP/RT-QuIC), which enables the detection of pathogenic α-synuclein seeds in the serum of individuals with synucleinopathies. In our internal first and second…

• JA
  Japan Agency for Medical Research and Development

  Awards: 20dm0107156, 21dk0207055, 21ak0101112, 21wm0425015, 21dm0207070
• JS
  Japan Society for the Promotion of Science

  Awards: 21wm0425015, 21H04820, 21K07424, 19K16928