articleNature MedicineMay 29, 2023HYBRID OA

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

BBBruna BellaverGPGuilherme PovalaPCPâmela C.L. FerreiraJPJoão Pedro Ferrari‐SouzaDTDouglas Teixeira Leffa

Universidade Federal do Rio Grande do Sul · University of Pittsburgh · +19 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. In vitro evidence suggests that reactive astrocytes unleash Aβ effects in pathological tau phosphorylation. Here, in a biomarker study across three cohorts ( n = 1,016), we tested whether astrocyte reactivity modulates the association of Aβ with tau phosphorylation in CU individuals. We found that Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast + ).…

Citation impact

305
total citations
FWCI
51.88
Percentile
100%
References
56
Citations per year

Authors

33

Topics & keywords

Topics
Keywords
  • Astrocyte
  • Pathological
  • Pathophysiology
  • Alzheimer's disease
  • Biomarker
  • Tau pathology
  • Phosphorylation
  • Neuroscience
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding