Highly lethal genotype I and II recombinant African swine fever viruses detected in pigs
Chinese Academy of Agricultural Sciences · Harbin Veterinary Research Institute · +1 more institution
Abstract
African swine fever virus (ASFV) poses a great threat to the global pig industry and food security. Currently, 24 ASFV genotypes have been reported but it is unclear whether recombination of different genotype viruses occurs in nature. In this study, we detect three recombinants of genotype I and II ASFVs in pigs in China. These recombinants are genetically similar and classified as genotype I according to their B646L gene, yet 10 discrete fragments accounting for over 56% of their genomes are derived from genotype II virus. Animal studies with one of the recombinant viruses indicate high lethality and transmissibility in pigs, and deletion of the virulence-related genes MGF_505/360 and EP402R derived from…
Citation impact
- FWCI
- 73.71
- Percentile
- 100%
- References
- 51
Authors
14- DZDongming Zhao
Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute
- ESEncheng Sun
Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute
- LHLianyu Huang
Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute
- LDLeilei Ding
Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute
- YZYuanmao Zhu
Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute
Topics & keywords
- Genotype
- Virulence
- Biology
- Virology
- African swine fever virus
- Recombinant DNA
- Virus
- Gene