Peptides as multifunctional players in cancer therapy
Kyungpook National University · National University · +1 more institution
Abstract
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue penetration and cell internalization than antibodies. Regardless of the pros and cons of peptides, they have been used as tumor-homing ligands for delivering carriers (such as nanoparticles, extracellular vesicles, and cells) and cargoes (such as cytotoxic peptides and radioisotopes) to tumors. Additionally, tumor-homing peptides have been conjugated with cargoes such as small-molecule or chemotherapeutic drugs via linkers to synthesize peptide-drug conjugates. In addition, peptides selectively bind to cell surface receptors and proteins, such as immune checkpoints,…
Citation impact
- FWCI
- 28.64
- Percentile
- 100%
- References
- 148
Authors
8- SMSri Murugan Poongkavithai VadevooCorresponding
Kyungpook National University, National University
- SGSmriti Gurung
Kyungpook National University, National University
- HLHyun‐Su Lee
Daegu Catholic University
- GRGowri Rangaswamy Gunassekaran
Kyungpook National University, National University
- SLSeok-Min Lee
Kyungpook National University, National University
Topics & keywords
- Cancer therapy
- Cancer
- Medicine
- Internal medicine
- Good health and well-being