articleScienceJun 1, 2023GREEN OA

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

BZBingxin ZhaoTLTengfei LiZFZirui FanYYYue YangJSJuan Shu

Purdue University West Lafayette · University of Pennsylvania · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and functional networks. We identified 80 associated genomic loci ( P < 6.09 × 10 −10 ) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian…

Citation impact

215
total citations
FWCI
62.91
Percentile
100%
References
154
Citations per year

Authors

19

Topics & keywords

Topics
Keywords
  • Mendelian randomization
  • White matter
  • Magnetic resonance imaging
  • Phenotype
  • Genome-wide association study
  • Human brain
  • Neuroscience
  • Functional magnetic resonance imaging
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding