Biofilm Microenvironment‐Responsive Self‐Assembly Nanoreactors for All‐Stage Biofilm Associated Infection through Bacterial Cuproptosis‐like Death and Macrophage Re‐Rousing
University of Science and Technology of China · Shanghai Jiao Tong University · +5 more institutions
Abstract
Abstract Bacterial biofilm‐associated infections (BAIs) are the leading cause of prosthetic implant failure. The dense biofilm structure prevents antibiotic penetration, while the highly acidic and H 2 O 2 ‐rich biofilm microenvironment (BME) dampens the immunological response of antimicrobial macrophages. Conventional treatments that fail to consistently suppress escaping planktonic bacteria from biofilm result in refractory recolonization, allowing BAIs to persist. Herein, a BME‐responsive copper‐doped polyoxometalate clusters (Cu‐POM) combination with mild photothermal therapy (PTT) and macrophage immune re‐rousing for BAI eradication at all stages is proposed. The self‐assembly of Cu‐POM in BME converts…
Citation impact
- FWCI
- 22.42
- Percentile
- 100%
- References
- 56
Authors
13- JMJiawei Mei
University of Science and Technology of China
- DXDongdong Xu
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- LWLingtian Wang
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- LKLingtong Kong
Second Military Medical University, Changhai Hospital
- QLQuan Liu
University of Science and Technology of China
Topics & keywords
- Biofilm
- Microbiology
- Bacteria
- Immune system
- Phagocytosis
- CD163
- Polyoxometalate
- Macrophage