Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer

Colorectal cancer (CRC) is the most common cancer of the digestive system with high mortality and morbidity rates. Gut microbiota is found in the intestines, especially the colorectum, and has structured crosstalk interactions with the host that affect several physiological processes. The gut microbiota include CRC-promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, and Bacteroides fragilis, and CRC-protecting bacterial species, such as Clostridium butyricum, Streptococcus thermophilus, and Lacticaseibacillus paracasei, which along with other microorganisms, such as viruses and fungi, play critical roles in the development of CRC. Different bacterial features are identified in…

• NN
  National Natural Science Foundation of China

  Awards: 2018YFA0800700, 82130022, 82273104, 62173005, 81972702, 91959110, 31925021
• NH
  National Health and Family Planning Commission of the People's Republic of China

  Award: 2020YB57
• PU
  Peking University
• PU
  Peking University Third Hospital
• NH
  National Health Commission of the People's Republic of China
• NK
  National Key Research and Development Program of China

  Award: 2018YFA0800700