Preoperative Treatment of Locally Advanced Rectal Cancer
Memorial Sloan Kettering Cancer Center · Mayo Clinic · +20 more institutions
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Abstract
Background
Pelvic radiation plus sensitizing chemotherapy with a fluoropyrimidine (chemoradiotherapy) before surgery is standard care for locally advanced rectal cancer in North America. Whether neoadjuvant chemotherapy with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) can be used in lieu of chemoradiotherapy is uncertain.
Methods
We conducted a multicenter, unblinded, noninferiority, randomized trial of neoadjuvant FOLFOX (with chemoradiotherapy given only if the primary tumor decreased in size by
Citation impact
434
total citations
- FWCI
- 93.74
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- 100%
- References
- 27
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Authors
25Topics & keywords
Topics
Keywords
- FOLFOX
- Medicine
- Hazard ratio
- Oxaliplatin
- Colorectal cancer
- Chemoradiotherapy
- Clinical endpoint
- Surgery
UN Sustainable Development Goals
- Good health and well-being
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Funding
- AFAlliance for Clinical Trials in Oncology FoundationAward: U10CA180821
- ACAmerican College of Radiology Imaging NetworkAwards: U10CA180820, U10CA180868, U10CA180888, U10CA180863
- ECECOG-ACRIN Cancer Research GroupAwards: U10CA180888, UG1CA233180, U10CA180868, U10CA180821, UG1CA189823, U10CA180820
- NONRG OncologyAwards: U10CA180882, U10CA180888, UG1CA189823, U10CA180820, U10CA180868
- SASchweizerische Arbeitsgemeinschaft für Klinische Krebsforschung
- NINational Institutes of HealthAwards: P30 CA008748, U10CA180882, UG1CA233180, P30CA006516, UG1CA233290, U10CA180868, UG1CA233329, UG1CA233373, U10CA180821, U10CA180888, U10CA180820, UG1CA232760, UG1CA189823, U10CA180863
- NCNational Cancer InstituteAwards: UG1CA233329, UG1CA232760, UG1CA233290, UG1CA189823, U10CA180868, U10CA180820, CA008748, U10CA180821, UG1CA233180, U10CA180882, P30 CA008748, P30CA006516, U10CA180863, U10CA180888, UG1CA233373