Gut bacterial metabolism contributes to host global purine homeostasis
University of Wisconsin–Madison · Nanyang Technological University · +6 more institutions
Abstract
The microbes and microbial pathways that influence host inflammatory disease progression remain largely undefined. Here, we show that variation in atherosclerosis burden is partially driven by gut microbiota and is associated with circulating levels of uric acid (UA) in mice and humans. We identify gut bacterial taxa spanning multiple phyla, including Bacillota, Fusobacteriota, and Pseudomonadota, that use multiple purines, including UA as carbon and energy sources anaerobically. We identify a gene cluster that encodes key steps of anaerobic purine degradation and that is widely distributed among gut-dwelling bacteria. Furthermore, we show that colonization of gnotobiotic mice with purine-degrading bacteria…
Citation impact
- FWCI
- 29.26
- Percentile
- 100%
- References
- 113
Authors
9Topics & keywords
- Biology
- Purine metabolism
- Purine
- Bacteria
- Gut flora
- Catabolism
- Uric acid
- Microbial metabolism