The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks

Ferroptosis is an iron-driven cell death modality characterized by iron accumulation and excessive lipid peroxidation. Ferroptosis is closely related to mitochondrial function, as indicated by studies showing that mitochondrial dysfunction and damage promote oxidative stress, which in turn induces ferroptosis. Mitochondria play crucial roles in cellular homeostasis, and abnormalities in their morphology and function are closely associated with the development of many diseases. Mitochondria are highly dynamic organelles, and their stability is maintained through a series of regulatory pathways. Mitochondrial homeostasis is dynamically regulated, mainly via key processes such as mitochondrial fission,…

• NN
  National Natural Science Foundation of China

  Awards: No. 82103553, 82103553, 2020-1
• CM
  Capital Medical University

  Awards: Z171100001017077, 1192070312, Z191100006619038
• BM
  Beijing Municipal Science and Technology Commission

  Awards: No. Z191100006619038, No. Z171100001017077, Z191100006619038, Z171100001017077, No. Z191100006619038, 1192070312