Radiochemistry for positron emission tomography
Harvard University · Emory University · +3 more institutions
Abstract
Positron emission tomography (PET) constitutes a functional imaging technique that is harnessed to probe biological processes in vivo. PET imaging has been used to diagnose and monitor the progression of diseases, as well as to facilitate drug development efforts at both preclinical and clinical stages. The wide applications and rapid development of PET have ultimately led to an increasing demand for new methods in radiochemistry, with the aim to expand the scope of synthons amenable for radiolabeling. In this work, we provide an overview of commonly used chemical transformations for the syntheses of PET tracers in all aspects of radiochemistry, thereby highlighting recent breakthrough discoveries and…
Citation impact
- FWCI
- 58.08
- Percentile
- 100%
- References
- 274
Authors
5- JRJian RongCorresponding
Harvard University, Emory University, Massachusetts General Hospital
- AHAhmed Haider
Harvard University, Emory University, Massachusetts General Hospital
- TETroels E. Jeppesen
Harvard University, Massachusetts General Hospital
- LJLee Josephson
Harvard University, Massachusetts General Hospital
- SHSteven H. Liang
Emory Healthcare, Harvard University, Emory University, Emory University Hospital, Massachusetts General Hospital
Topics & keywords
- Positron emission tomography
- Pet imaging
- Molecular imaging
- Medical physics
- Preclinical imaging
- Nanotechnology
- Nuclear medicine
- Computer science
- Good health and well-being
Funding
- NSNational Science Foundation
- EUEmory University
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungAwards: DA043507, DA038000
- NINational Institutes of HealthAwards: MH120197, AG074218, AG079956, MH128705, MH117125, AG070060, AG073428, DA038000, AG080262, AG063290, AG075444, AG078058, DA043507
- SOSchool of Medicine, Emory University