Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Moliner, Rafael; Girych, Mykhailo; Brunello, Cecilia A.; Kovaleva, Vera; Biojone, Caroline; Enkavi, Giray; Antenucci, Lina; Kot, Erik F.; Goncharuk, Sergey A.; Kaurinkoski, Katja; Kuutti, Mirjami; Fred, Senem Merve; Elsilä, Lauri; Sakson, Sven; Cannarozzo, Cecilia; Diniz, Cassiano R.A.F.; Seiffert, Nina; Rubiolo, Anna; Haapaniemi, Hele; Meshi, Elsa; Nagaeva, Elina; Öhman, Tiina; Róg, Tomasz; Kankuri, Esko; Vilar, Marçal; Varjosalo, Markku; Korpi, Esa R.; Permi, Perttu; Минеев, Константин С.; Saarma, Märt; Vattulainen, Ilpo; Casarotto, Plínio; Ċastrén, Eero

doi:10.1038/s41593-023-01316-5

articleNature NeuroscienceJun 1, 2023HYBRID OA

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

RMRafael Moliner MGMykhailo Girych CACecilia A. Brunello VKVera Kovaleva CBCaroline Biojone

University of Helsinki · Aarhus University · +10 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We recently reported that pharmacologically diverse antidepressants, including fluoxetine and ketamine, act by binding to TrkB, the receptor for BDNF. Here we show that lysergic acid diethylamide (LSD) and psilocin directly bind to TrkB with affinities 1,000-fold higher than those for other antidepressants, and that psychedelics and antidepressants bind to distinct but partially overlapping sites within the transmembrane domain of TrkB dimers. The effects of psychedelics on neurotrophic signaling, plasticity and antidepressant-like behavior in mice…

Citation impact

422

total citations

FWCI: 125.89
Percentile: 100%
References: 92

Citations per year

Authors

33

Topics & keywords

Topics

Keywords

Tropomyosin receptor kinase B
Neuroscience
Neuroplasticity
Psychology
Brain-derived neurotrophic factor
Receptor
Neurotrophic factors
Biology

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.