Taurine deficiency as a driver of aging

Singh, Parminder; Gollapalli, Kishore; Mangiola, Stefano; Schranner, Daniela; Yusuf, Mohd Aslam; Chamoli, Manish; Shi, Sting L.; Lopes-Bastos, Bruno; Nair, Tripti; Riermeier, Annett; Vayndorf, Elena; Wu, Judy; Nilakhe, Aishwarya; Nguyen, Christina Q.; Muir, Michael; Kiflezghi, Michael G.; Foulger, Anna; Junker, Alex; Devine, Jack; Sharan, Kunal; Chinta, Shankar J.; Rajput, Swati; Rane, Anand; Baumert, Philipp; Schönfelder, Martin; Iavarone, Francescopaolo; Lorenzo, Giorgia Di; Kumari, Swati; Gupta, Alka; Sarkar, Rajesh; Khyriem, Costerwell; Chawla, Amanpreet Singh; Sharma, Ankur; Sarper, Nazan; Chattopadhyay, Naibedya; Biswal, B.K.; Settembre, Carmine; Nagarajan, Perumal; Targoff, Kimara L.; Picard, Martin; Gupta, Sarika; Velagapudi, Vidya; Papenfuss, Anthony T.; Kaya, Alaattin; Ferreira, Miguel Godinho; Kennedy, Brian K.; Andersen, Julie K.; Lithgow, Gordon J.; Ali, Abdullah Mahmood; Mukhopadhyay, Arnab; Palotie, Aarno; Kastenmüller, Gabi; Kaeberlein, Matt; Wackerhage, Henning; Pal, Bhupinder; Yadav, Vijay K.

doi:10.1126/science.abn9257

articleScienceJun 8, 2023GOLD OA

Taurine deficiency as a driver of aging

PSParminder Singh KGKishore Gollapalli SMStefano Mangiola DSDaniela Schranner MAMohd Aslam Yusuf

National Institute of Immunology · Columbia University · +26 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus,…

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Topics & keywords

Topics

Keywords

Taurine
Life span
Senescence
Endocrinology
Telomerase
Internal medicine
Biology
Healthy aging

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