An integrated cell atlas of the lung in health and disease

Sikkema, Lisa; Ramírez-Suástegui, Ciro; Strobl, Daniel; Gillett, Tessa E.; Zappia, Luke; Madissoon, Elo; Markov, Nikolay S.; Zaragosi, Laure‐Emmanuelle; Ji, Yuge; Ansari, Meshal; Arguel, Marie‐Jeanne; Apperloo, Leonie; Banchero, Martin; Bécavin, Christophe; Berg, Marijn; Chichelnitskiy, Evgeny; Chung, Mei-I; Collin, Antoine; Gay, Aurore; Gote-Schniering, Janine; Kashani, Baharak Hooshiar; İnecik, Kemal; Jain, Manu; Kapellos, Theodore S.; Kole, Tessa; Leroy, Sylvie; Mayr, Christoph H.; Oliver, Amanda J.; Papen, Michael von; Peter, Lance; Taylor, Chase J.; Walzthoeni, Thomas; Xu, Chuan; Bui, Linh T.; Donno, Carlo De; Dony, Leander; Faiz, Alen; Guo, Minzhe; Gutierrez, Austin J.; Heumos, Lukas; Huang, Ni; Ibarra, Ignacio L.; Jackson, Nathan D.; Murthy, Preetish Kadur Lakshminarasimha; Lotfollahi, Mohammad; Tabib, Tracy; Talavera‐López, Carlos; Travaglini, Kyle J.; Wilbrey-Clark, Anna; Worlock, Kaylee B.; Yoshida, Masahiro; Chen, Yuexin; Hagood, James S.; Agami, Ahmed; Horváth, Péter; Lundeberg, Joakim; Marquette, Charles‐Hugo; Pryhuber, Gloria; Samakovlis, Chistos; Sun, Xin; Ware, Lorraine B.; Zhang, Kun; Berge, Maarten van den; Bossé, Yohan; Desai, Tushar; Eickelberg, Oliver; Kaminski, Naftali; Krasnow, Mark A.; Lafyatis, Robert; Nikolić, Marko; Powell, Joseph E.; Rajagopal, Jayaraj; Rojas, Mauricio; Rozenblatt–Rosen, Orit; Seibold, Max A.; Sheppard, Dean; Shepherd, Douglas P.; Sin, Don D.; Timens, Wim; Tsankov, Alexander M.; Whitsett, Jeffrey A.; Xu, Yan; Banovich, Nicholas E.; Barbry, Pascal; Duong, Thu Elizabeth; Falk, Christine S.; Meyer, Kerstin B.; Kropski, Jonathan A.; Pe’er, Dana; Schiller, Herbert B.; Tata, Purushothama Rao; Schultze, Joachim L.; Teichmann, Sara A.; Misharin, Alexander V.; Nawijn, Martijn C.; Luecken, Malte D.; Theis, Fabian J.

doi:10.1038/s41591-023-02327-2

articleNature MedicineJun 1, 2023HYBRID OA

An integrated cell atlas of the lung in health and disease

LSLisa Sikkema CRCiro Ramírez-Suástegui DSDaniel Strobl TETessa E. Gillett LZLuke Zappia

Helmholtz Zentrum München · Technical University of Munich · +60 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations of individual studies and capture the variability present in the population. Here we present the integrated Human Lung Cell Atlas (HLCA), combining 49 datasets of the human respiratory system into a single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents a consensus cell type re-annotation with matching marker genes, including annotations of rare and previously undescribed cell types. Leveraging the number and diversity of…

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Topics & keywords

Topics

Keywords

Annotation
Atlas (anatomy)
Population
Computational biology
Biology
Cell type
Disease
Cell

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