Alcohol consumption and risks of more than 200 diseases in Chinese men

Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped for ALDH2- rs671 and ADH1B- rs1229984 , with >1.1 million ICD-10 coded hospitalized events. At baseline, 33% of men drank alcohol regularly. Among men, alcohol intake was positively associated with 61 diseases, including 33 not defined by the World Health Organization as alcohol-related, such as cataract (n = 2,028; hazard ratio 1.21; 95% confidence interval 1.09-1.33, per 280 g per week) and gout (n = 402;…

• G
  GlaxoSmithKline
• CR
  Cancer Research UK

  Awards: A29186, 088158/Z/09/Z, MC_UU_00017/1, 2016YFC0900500, CH/1996001/9454, 212946/Z/18/Z, 104085/Z/14/Z, C16077/A29186, 202922/Z/16/Z
• BH
  British Heart Foundation

  Awards: 104085/Z/14/Z, CH/1996001/9454, RE/18/3/34214, 088158/Z/09/Z, C16077/A29186, 2016YFC0900500, MC_UU_00017/1, 212946/Z/18/Z, 202922/Z/16/Z
• UO
  University of Oxford

  Awards: 104085/Z/14/Z, 202922/Z/16/Z, 212946/Z/18/Z, 088158/Z/09/Z
• NN
  National Natural Science Foundation of China

  Awards: 2016YFC0900500, 104085/Z/14/Z, 212946/Z/18/Z, 202922/Z/16/Z, 088158/Z/09/Z, 82192904, 82192901, C16077/A29186, MC_UU_00017/1, CH/1996001/9454, 82192900
• CC
  Chinese Center for Disease Control and Prevention
• KC
  Kadoorie Charitable Foundation

  Awards: CH/1996001/9454, MC_UU_00017/1, 212946/Z/18/Z, 2016YFC0900500, 202922/Z/16/Z, C16077/A29186, 088158/Z/09/Z, 104085/Z/14/Z
• CF
  Centers for Disease Control and Prevention
• MR
  Medical Research Council

  Awards: MC_UU_00017/1, MC-PC-13049, 2016YFC0900500, MC_PC_14135, 104085/Z/14/Z, CH/1996001/9454, MC_UU_00017/1, 088158/Z/09/Z, 212946/Z/18/Z, 202922/Z/16/Z, MC_U137686851, MC_UU_00017/1, MC_UU_12026/2, MC_U137686851, MC_UU_12026/2, C16077/A29186, MC-PC-14135, MC_PC_13049
• NK
  National Key Research and Development Program of China

  Awards: MC_UU_00017/1, 088158/Z/09/Z, 2016YFC0900500, 202922/Z/16/Z, 104085/Z/14/Z, CH/1996001/9454, C16077/A29186, 212946/Z/18/Z