Inflammation and aging: signaling pathways and intervention therapies
First Affiliated Hospital Zhejiang University · Zhejiang University · +3 more institutions
Abstract
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there is an urgent need for a systematic organization of inflammaging through dimensionality reduction. Factors secreted by senescent cells, known as the senescence-associated secretory phenotype (SASP), promote chronic inflammation and can induce senescence in normal cells. At the same time, chronic inflammation accelerates the senescence of immune cells, resulting in weakened immune function and an inability to clear senescent cells and inflammatory factors, which creates a vicious cycle of…
Citation impact
- FWCI
- 206.43
- Percentile
- 100%
- References
- 480
Authors
6- XLXia LiCorresponding
First Affiliated Hospital Zhejiang University, Zhejiang University
- CLChentao Li
Zhejiang University-University of Edinburgh Institute, Zhejiang University
- WZWanying Zhang
Zhejiang University-University of Edinburgh Institute
- YWYanan Wang
Zhejiang University-University of Edinburgh Institute
- PQPengxu Qian
Zhejiang Lab, First Affiliated Hospital Zhejiang University, Zhejiang University
Topics & keywords
- Inflammation
- Immunosenescence
- Senescence
- Immune system
- Immunology
- Disease
- Medicine
- Biology